In this webinar, we have invited two experts – Professor Santiago Munné from Spain and Professor Yanwen Xu from China, who will be sharing with us more on PGT-A.

Professor Santiago Munné will be speaking to us about PGT-A in the presentation titled “Are Aneuploidy Rates Affected by ART Practice?” He will be sharing the limitations of actual PGT-A in terms of inconsistency of doctor’s skill for embryo biopsy, controlled ovarian stimulation methods, follicular size and culture conditions (culture media, temperature, changes in PH, oxygen concentration, osmolarity, continuous vs. sequential, low lactate vs. high lactate and luteal support). He recommends metabolomics as a next frontier to overcome drawbacks of current PGT-A and automated ART procedures to decrease repetitive and error-prone aspects of ART.

Professor Yanwen Xu will be speaking on “Using PGT-A Wisely: When and How?” She will analyze the current conditions in China from a clinical point of view. She insists that PGT-A is beneficial to patients suffering from repeated miscarriages due to advanced age when it is performed with highly-qualified skill for biopsy and cryopreservation but she also points out that this ART has not yet been established and many challenges still remain.

Watch the lecture recordings below and take advantage of your opportunity to ask questions about this exciting area of reproductive medicine. Questions will be addressed at the live forum session taking place on Saturday, 7 November 2020 at 3pm GMT (+8).

Lecture 1: Are Aneuploidy Rates Affected by ART Practice?

Speaker: Dr. Santiago Munné (Madrid, Spain) [click to view speaker’s bio]

Chromosome abnormalities increase with advancing maternal age, but can also have a iatrogenic origin. Our research shows that PGT results from egg donors’ cycles vary greatly between center to center, even when egg donors are all young and selected in similar ways. Further study of egg donor cycles identified that the fraction of gonadotropin that is hMG was correlated with euploidy. Other studies have shown that unsuitable temperature and Ph conditions, type of culture media, and type of plastics can contribute to chromosome abnormalities. We are currently investigating metabolomics of embryos to determine best conditions, as well as automation devices to minimize manipulation and human error.

Have questions pertaining to this lecture? Leave your questions in the comment box below or send them to Questions collected will be addressed at the live forum session happening on Saturday, 7 November 2020 at 3pm (GMT+8).

Lecture 2: Using PGT-A Wisely – When and How?

Speaker: Professor Yanwen Xu (Guangzhou, China) [click to view speaker’s bio]

The aim of PGT-A was to increase CPRs per ET and decrease miscarriage rates, thus to Increase the application of SET, and reduce time to get pregnancy. The indications for PGT-A include: AMA, RIF, SMF, and RM. This presentation will focus on the application of PGT-A in different age groups.

First of all, we need to understand the nature of PGT-A is to select embryos before transfer, not to improve embryo quality. Through PGT-A, we can increase implantation in the first ET cycles, and decrease miscarriage rate. However, PGT-A may result in approximately 20% consumption due to TE biopsy, mosaicism, and cryopreservation. In three RCTs, we can see that PGT-A may benefit group of patients with high aneuploidy rate, but not for young patients with low aneuploidy rate.

In PGT practice, stable blastocyst formation rate, high survival rates after biopsy and vitrification are the guarantee to minimize the consumption of PGT-A. The PGT method used should have been previously implemented, tested and validated in the PGT center, thus to maximize the benefit of PGT-A. Adequate labelling system is needed to match the sample’s diagnostic result with the embryo from which the sample was taken. Genetic counseling for the patients related to the IVF treatment and the genetic analysis are needed. The exact age group for AMA should be determined by each PGT center, considering the benefit and consumption.

Have questions pertaining to this lecture? Leave your questions in the comment box below or send them to Questions collected will be addressed at the live forum session happening on Saturday, 7 November 2020 at 3pm (GMT+8).


Watch our forum session which was held on Saturday, 7 November 2020 at 3pm (GMT+8).

Moderator: Professor Atsushi Tanaka (Fukuoka, Japan)

Panellists: Dr. Santiago Munné (Madrid, Spain), Professor Yanwen Xu (Guangzhou, China)